Logitech M221 Wireless mouse users have complained about specific issues with their mouse. The primary one is the non-functionality of the mouse buttons: the left-click and the right-click buttons. When the click buttons are not working on a computer, the problem could be related to the mouse’s hardware or the PC’s software.

This article will guide you on what you need to resolve this problem with a Logitech M221 Wireless mouse. But before getting to the solutions, you need to figure out whether the problem is with the mouse or the PC. Because if the issue is with the mouse, you need to either repair it or replace it entirely. Whatever may be the case, we will look into all possible solutions. So without any further ado, let’s get into it.

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How to Fix Logitech M221 Wireless Mouse Left-Click/Right-Click Not working issue?

As mentioned above, the problem could be related to hardware or software. And to figure that out, you need to test the mouse with another computer. You can either use a secondary computer in your home or call out to a friend asking him to help figure out the problem with his laptop. Once you insert the USB dongle of the mouse onto the other computer, if all the buttons work fine, then the problem is with the software, and you need to try the solutions mentioned below.

But if it is not working even on a different computer, then the issue is with the hardware. If you have little to no experience in taking a mouse apart and fixing it, the repairing process will be tiresome. You can visit your nearest Logitech service center, and they will help you out. But sometimes, a replacement is much easier than going through all the hassles of a repair.

Now, let’s get into the software solutions.

Change the USB port for the dongle:

The Logitech M221 wireless mouse comes with a USB dongle. The user needs to plug the dongle into a USB port of the computer where he wants to use the mouse. The USB dongle acts as a receiver for the mouse. But if the USB port you are using for the dongle is damaged, the connection will not be adequately established, and no matter what you do with the mouse, it will malfunction on your computer.

USB ports do malfunction sometimes in a PC. But not all of them will have the issue. Remove the USB dongle from the previously used port and put it in another USB port. Now try using the mouse again.

Try the next solution if the mouse scroll still does not work when connected via a different USB port.

Identify any problematic application:

Specific applications running on our computer often hinder the overall functionality of some devices connected to the computer. Some applications in the background might block even the mouse scroll function. These applications are usually patch or crack applications that compromise the machine’s security. Suppose you have recently installed any fishy application on your computer. It would be best if you uninstalled it from your computer right away.

  • Press Windows key + X and choose “Apps and Features” from the list of options that show up.
  • Then you will see a window with all your installed applications in one place. Find the fishy or recently installed application in this list and click on it.
  • Then click on the uninstall button that shows up right below it.
  • Now, follow the on-screen instructions to remove the application from your computer.

Move on to the next solution if uninstalling the application does not help with your scroll issue with the Logitech M221 Wireless mouse.

Fix Corrupted User Profile:

The mouse buttons not working issue is sometimes related to a user profile. And to check whether that is the issue, you need first to create a different new profile.

  • Press Windows key + X and choose Settings from the list of options that show up.
  • Inside settings, navigate to Accounts > Family and Other Users> Add Someone Else to This PC.

Now set up a username and password for the new account. Once everything is set up, log in to that account and check whether the mouse buttons are working well or not. If they are working fine, then you have successfully found the issue. It is due to a corrupted user profile.

To fix this, move everything over from one profile to another and then login into that new account. Then keep using the mouse on the new account without any issues.

However, if the mouse buttons do not work even with the new account, the problem is not with the user profile. In that case, move on to the next solution below.

Check for Corrupted Windows Data:

Sometimes Windows file corruption can even cause the device to malfunction on your computer. Windows has a built-in utility that can scan for issues and even fix them if it finds anything wrong with it. You will have to use the command prompt window here.

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  • Press Windows key + X and choose Windows PowerShell(Admin) from the list of options that show up.
  • In the window that shows up, enter the following command and press Enter.

sfc /scannow

  • Let the process complete.

After this, restart your computer and recheck your mouse. If the click buttons are still not working, move on to the next solution.

Hard Reset Your Computer:

If you have tweaked around the settings in your computer, then by some error, you could have disabled the mouse buttons on your computer. In such a scenario, a simple Windows reset can eliminate all problems.

The hard reset has solved the mouse click issue for many users, even for mice from different manufacturers. So give it a try with your Logitech M221 as well.

For the hard reset, the process is different depending on the type of computer you are using. If it is desktop, removing the power cord from the source and keeping the system idle for a while is enough. But for laptop users, you need to remove the plug from the power socket and remove the battery from the bottom of the laptop. Then keep the system idle for a while before putting the battery back in.

Try the next solution if the hard reset does not do you any good with your issue with the mouse.

Enable ClickLock:

Clicklock is a feature that lets you drag and drop files and folders using single mouse clicks. You don’t need to hold down the left mouse button physically.

Turning it on can fix your issue with the click button. So give it a shot as well.

  • Press Windows key + X and choose Settings from the list of options that show up.
  • Inside settings, navigate to Devices > Mouse > Related Settings > Additional Mouse Options.

At the bottom, you will see the ClickLock option. Tick the checkbox next to it to enable it on your computer. Once that is done, close every window and reconnect the mouse to your computer.

Try the following solution mentioned below if even this does not solve your problem with the mouse.

Reinstall the Mouse drivers:

Windows automatically installs the drivers for most devices when connected to the system. When the Logitech M221 wireless mouse was connected for the first time, it did the same. But sometimes, that installation can have some inconsistencies. To fix that, you need to install the mouse drivers again.

  • Press the Windows Key + X and choose Device Manager from the options.
  • In the Device Manager window, find Mice and other pointing devices.
  • Double-click on it once you find it, and the list of installed mouse drivers will show up.
  • Here, you will find the Logitech wireless mouse as well. Once you see it, right-click on it and choose Uninstall device.
  • The Uninstall Device window will show up. Click on the Uninstall button, and the device will be removed from the computer.
  • Now, go back to the Device Manager window and right-click on Mice and other pointing devices.
  • Then select the Scan for hardware changes option. This will install the drivers for your mouse again. Just do not disconnect the mouse from your computer during the entire process.

Try the next solution if the reinstallation also does not fix the mouse issue.

Download and install the latest drivers:

Windows need up-to-date drivers to stay compatible with every possible device out there. So if you are on outdated drivers, update the mouse drivers right away. That might solve your problem with the Logitech M221 wireless mouse left-click and right-click not working issue.

There are three ways to update a driver. You can do it automatically, manually, or using a third-party application.

To do it automatically, you can use Windows device manager.

  • Press and hold Windows Key + X and choose “Device Manager” from the list of options.
  • In the Device Manager window, find Mice and other pointing devices.
  • Double-click on it once you find it, and the list of installed mouse drivers will show up.
  • Here, you will find the Logitech wireless mouse as well. Once you see it, right-click on it and choose “Update driver.”
  • Choose “Search automatically for updated driver software.”
  • Follow the on-screen instructions and install the driver update that shows up.

You need to visit the Logitech support website for the manual process and look for the driver setup file. It will be like any other software installation file. Once you find the setup file, install it on your computer as with any other application.

Besides these two methods, you also have a third option. You can install a third-party driver utility tool on your computer, and it will automatically scan your computer for any outdated or missing drivers. It will also install the latest drivers on your computer with a simple click. However, these utility software tools usually have a price tag. But the price is well worth it as you don’t need to worry about drivers on your computer even again.

One of the solutions mentioned above will fix your Logitech M221 Wireless Mouse issue’s button click issue. If you have any questions or queries about this article, comment below, and we will get back to you. Also, check out our other articles on iPhone tips and tricks, Android tips and tricks, PC tips and tricks, and much more for more helpful information.